From the New World

Saki and Niimi, her coworker, decide to head to the Temple of Purity, as Kaburagi declares war on the Monster Rats, promising to eliminate them from Japan. But the Ogre approaches, killing many humans as it comes to confront Kaburagi. Saki sees the Ogre and is shocked by its resemblance to Maria. Satoru appears and tells Saki and Niimi that they have to leave as soon as possible, since even Kaburagi cannot kill an Ogre. Though Kaburagi manages to evade the Ogre's first attack, she kills him. Saki and the others run, confronting a Monster Rat along the way who tells them that the Monster Rat race will now be the new rulers, and that their "Messiah," the Ogre, was sent from the heavens to save them. They kill the Rat, and Niimi tells them he must leave them and go to the Town Hall. Saki and Satoru make it to the Temple of Purity, where they learn that Saki's parents have already been there and plan to release the remaining Impure Cats upon the Ogre. They also meet up with Inui, who tells them about his group's failed mission to dispose of the Robber Fly colony and his first encounter with the Ogre. When he made it back to the village alone following his group's death, he found the hospital burned down and all the human infants stolen. It is then that Saki realizes that Yakomaru killed Maria and Mamoru, took their child, and raised it to become an Ogre. He plans to do the same with the stolen infants, creating an army of Ogres that will wipe the humans off the face of the Earth and bring rise to a Monster Rat empire.

1000 years after 2011, society has advanced, and most people in the Japan archipelago have psychokinetic powers, know as their Cantus. Join the main character Watanabe Saki as she finds out horrifying truths and recognizing true feelings about Kamisu's 66th District.

In the aftermath of the Monster Rats' sneak attack, Saki and Satoru join up with another group and accompany them to the hospital to check on one of their injured friends. As they arrive, they find the hospital destroyed. After clearing the place of the Monster Rats and rescuing the few survivors, the party is attacked by an unknown individual who kills everyone in its path with an overwhelming power. Fearing that the enemy in question may be an Ogre, the other members of the party decide to sacrifice themselves to let Saki and Satoru to escape and warn the others; however, as they flee along the river, the duo soon realize that they are being followed by the enemy.